Urinary β2-microglobulin (β2-MG)

Examination of urinary β2-microglobulin introduces that β2-microglobulin is produced in lymphocytes, and its content in urine is very small. Because of its small molecular weight, it can freely pass through the glomerular filtration membrane. The β2 microglobulin filtered by glomerulus is almost completely reabsorbed through the renal tubule. If the excretion of urinary β2-microglobulin is increased, the renal tubular reabsorption disorder is called renal tubular proteinuria, which is different from Albumin-based glomerular proteinuria. In clinical urinalysis, urinary β2 microglobulin is of great significance for the detection of nephropathy. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Found in acute or chronic glomerulonephritis, nephrotic syndrome and so on. Normal value: Urine β2-MG: 31.5-100μg/24h Above normal: Found in proximal tubular damage, autoimmune diseases, malignant tumors, liver disease, rejection after organ transplantation, AIDS, etc. Urine β2 microglobulin increased in acute or chronic glomerulonephritis, uremia, diabetic nephropathy, systemic lupus erythematosus involving renal disease, pyelonephritis, congenital Fanconi syndrome, Wilson disease, cadmium metal poisoning, and intake of Qingda Medicine, nifedipine (heart pain), tobramycin and other drugs. negative: Positive: Tips: It is not advisable to have a urine test during a cold. Generally, you can do it after a week. It is also best not to leave urine for diarrhea. Normal value 31.5 ~ 100μg / 24h. Clinical significance Increase Found in proximal tubular damage, autoimmune diseases, malignant tumors, liver disease, rejection after organ transplantation, AIDS, etc. Urine β2 microglobulin increased in acute or chronic glomerulonephritis, uremia, diabetic nephropathy, systemic lupus erythematosus involving renal disease, pyelonephritis, congenital Fanconi syndrome, Wilson disease, cadmium metal poisoning, and intake of Qingda Medicine, nifedipine (heart pain), tobramycin and other drugs. reduce Found in acute or chronic glomerulonephritis, nephrotic syndrome and so on. Low results may be diseases: glomerulonephritis, nephrotic syndrome results may be high disease: uremia considerations 1, stay 24 hours of urine on the same day of normal diet, normal activities, do not deliberately drink too much water, neither can stay in bed nor too vigorous exercise. 2. When the weather is hot, some hospitals require preservatives to prevent the urine from deteriorating. The first urine collected after emptying the bladder at 7:00 on the first day is added to the container together with the preservative. However, it is best to add nothing, and the collected urine is most scientifically stored in the refrigerator. 3, during the cold period should not be done urine test, generally wait for a cold after a week to do. It is also best not to leave urine for diarrhea. 4, urine β2-microglobulin determination, can be estimated a certain drug damage to the kidney, such as with gentamicin, kanamycin or polymyxin, urine β2-microglobulin significantly increased, prompt to stop Drug or change other drugs. Inspection process RIA method. Not suitable for the crowd There are no taboos. Adverse reactions and risks No.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.