Urinary α1-microglobulin

Α1 microglobulin is a glycoprotein which is mainly synthesized in liver and lymphoid tissues and is widely distributed on body fluids and lymphocyte membrane surfaces. Determination of α1 microglobulin has a certain significance in diagnosing kidney disease and evaluating renal function. Urinary α1-MG has two types, free type and combined type. The free form can be filtered by the renal tubules, and the combined type cannot pass through the renal tubules. Pathological increase is seen in renal tubular damage, such as chronic renal failure, and there is a binding type in the urine. When α1—MG, it indicates that the glomerular filtration membrane is damaged. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: No relevant information. Normal value: Urine α1-microglobulin: 0.48-4.24mg/L Above normal: Found in pyelonephritis, potassium loss nephritis, renal vascular disease, myeloma, heavy metal poisoning. negative: Positive: Tips: It is not advisable to have a urine test during a cold. Generally, you can do it after a week. It is also best not to leave urine for diarrhea. Normal value Urine 0.48 ~ 4.24mg / L. Clinical significance Elevated urinary α1 microglobulin is found in pyelonephritis, potassium-depleted nephritis, renal vascular disease, myeloma, and heavy metal poisoning. High results may be diseases: heavy metal toxic nephropathy, multiple myeloma in the elderly 1, stay 24 hours of urine on the same day of normal diet, normal activities, do not deliberately drink too much water, neither can stay in bed nor too vigorous exercise. 2. When the weather is hot, some hospitals require preservatives to prevent the urine from deteriorating. The first urine collected after emptying the bladder at 7:00 on the first day is added to the container together with the preservative. However, it is best to add nothing, and the collected urine is most scientifically stored in the refrigerator. 3, during the cold period should not be done urine test, generally wait for a cold after a week to do. It is also best not to leave urine for diarrhea. Inspection process First, the urine sample was diluted 41 times: 50 μl of the urine sample was taken, 2.0 ml of the dilution buffer was added, shaken, room temperature 20 min, centrifuged at 3500 r/min for 20 min, the supernatant was discarded, and the precipitated CPM was measured. According to the percentage of each standard tube (B) and zero standard tube (B0), that is, B/B0×100% and the corresponding α1-m concentration of each standard tube, a standard curve is drawn on the semi-logarithmic paper. The B/B0% of the sample to be tested is found from the standard curve on the α1-m concentration of the sample, and the dilution factor is the concentration of the α1-m of the urine sample. Not suitable for the crowd It is not advisable to have a urine test during a cold, and generally wait for a cold for a week. Adverse reactions and risks No.

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