Urinary 17-ketogenic steroid

Urinary corticosteroid intermediates and metabolites, including urinary 17-hydroxycorticosteroid (17-OHCS), 17-ketosteroid (17-KS), 17-ketogenic steroid (17-KGS), and urinary trimerol. The determination of these substances can indirectly reflect the function of the adrenal cortex, and has certain diagnostic value for some special adrenal hyperplasia. The above detection methods have been seldom used due to the application of new and more sensitive methods for detecting adrenal function. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Tips: If the urine can not be measured in time, it should be stored in the refrigerator to avoid the destruction of 17-ketosteroids and reduce the result. First, a part of the urine is discarded to wash away the bacteria left in the urethra and anterior urethra, and then the middle part of the urine. Leave for inspection. Normal value Chemical assay 0 to 1 year old <3.5μmol/24h (<1.0mg/24h); 1 to 10 years old <17μmol/24h (<5mg/24h); 11 to 14 years old <42μmol/24h (<12mg/24h); Adult male 17 ~ 80μmol / 24h (5 ~ 23mg / 24h); Female 10 ~ 52μmol / 24h (3 ~ 15mg / 24h). Clinical significance (1) Elevation: Cushing's syndrome (cortisolism), congenital adrenal hyperplasia, adrenal adenoma, adrenal cancer, hyperthyroidism, simple obesity, ACTH treatment, stress status, etc. (2) Reduction: primary adrenal insufficiency (Addison's disease), anterior pituitary hypofunction, hypothyroidism, cirrhosis, systemic wasting disease, and when corticosteroid treatment is stopped. Low results may be diseases: liver cirrhosis, non-organic orgasm disorder results are high. Possible diseases: hyperthyroidism Requirements for inspection: 1, if the urine can not be measured in time, should be stored in the refrigerator to avoid the destruction of 17-ketosteroids and reduce the results. 2, first discharge a part of the urine to discard, in order to wash away the bacteria left in the urethra and the anterior urethra, and then the middle part of the urine to be taken for inspection. Preparation before inspection: 1. One day (24 hours) of the test, the diet should be scheduled according to normal conditions. Inspection process 1, low-dose dexamethasone inhibition test: first control day 24h urinary free cortisol test, then oral dexamethasone 0.5mg, every 6h1 times, a total of 2 days, medication on the second day to review 24h urinary free cortisol output Should be less than 20μg / 24h. 2, overnight dexamethasone inhibition test: blood test for cortisol at 8:00 am on the test day, oral dexamethasone 1mg at 11 o'clock on the same day, the next day at 8 o'clock in the morning to check the blood cortisol concentration should be > control value of 75 %. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Generally not.

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