Serum Immunoglobulin E (IgE)

IgE is a secreted immunoglobulin with a molecular weight of 196,000 and consists of two light chains and two heavy chains. It is produced by plasma cells in the lamina propria of the nasopharynx, tonsil, bronchus, gastrointestinal mucosa, etc. It is the main antibody causing type I allergic reaction. The most obvious basic biological characteristic is the affinity of the cell type, human IgE only It can sensitize human and monkey cells without allergic to other animals. IgE is the most unstable to heat in immunoglobulins. Among the five immunoglobulins, IgE has the shortest half-life, and has the highest decomposition rate and the lowest synthesis rate, so the serum content is the lowest. The normal human serum has an IgE value of about 0.1 to 0.9 mg/L, which is usually slightly higher in men than in women. In patients with allergies or hypersensitivity, serum IgE is significantly higher than normal, and exogenous asthma patients are several times higher than normal. Therefore, IgE is too high in serum, often suggesting the presence of genetic allergies, or type I allergies. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. Normal value The reference value is 0.1 to 0.9 mg/L (0.01 to 0.09 mg/dl). (Note the specific reference value depends on each laboratory.) Clinical significance (1) rise 1 simple increase in IgE multiple myeloma. 2 increased in diversity A, atopic disease, specific reactive bronchial asthma, allergic rhinitis, atopic dermatitis, allergic bronchopulmonary aspergillosis, and the like. B, parasitic infections. C, T cell dysfunction, high IgE syndrome, Wiskott-Aldrich syndrome (eczema thrombocytopenia multiple infection syndrome), DiGeroger syndrome (thymus hypoplasia syndrome), selective IgA deficiency, severe combined immune deficiency Wait. D, other diseases, soft tissue eosinophilic granuloma (Kimura disease), Hodgkig disease (Hodgkin's disease), acute hepatitis, cirrhosis, primary liver cancer, rheumatoid arthritis, Kawasaki disease, diarrhea in children, etc. (2) reduction 1 multiple myeloma (except IgE type). 2 low or no gamma-globulinemia (primary or secondary), ataxia - telangiectasia, severe complex immune function defects. 3 chronic paranasal sinus tumor, sarcoma-like disease, chronic lymphocytic leukemia. 4 silicosis, asbestosis and lungs. High results may be diseases: allergic conjunctivitis, senile asthma, tropical pulmonary eosinophilic infiltration, tropical pulmonary eosinophilic pneumonia, pulmonary eosinophilic infiltration precautions First, the precautions before blood draw 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. Second, should pay attention after blood draw 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process Same as IgG assay. Check the standard curve, calculate the corresponding content of IgE, and multiply by the dilution factor to determine the IgE content in the specimen. 1U = 2.4 ng. Not suitable for the crowd There are no special taboos. Adverse reactions and risks No relevant information.

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