Serum cryoglobulin (CG)

Serum cryoglobulin is also a gamma globulin, and gamma globulin is also an immunoglobulin. In normal human serum, cryoglobulin can be deposited in blood vessels, causing blood flow to be blocked and causing distal ischemia. Cryoglobulin is present in many clinical diseases and can fix complement to produce an inflammatory response similar to that caused by immune complexes. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: In order to prevent or reduce the loss of cryoglobulin, the syringe and the test tube should be pre-warmed first, and then the blood sample should be placed at 37 ° C for 2 h to allow the blood to coagulate and then separate. Normal value Spectrophotometry <80mg / L. (Note the specific reference value depends on each laboratory.) Clinical significance 1, CG elevation is seen in cryoglobulinemia. Clinically, it can be divided into monoclonal type (type I), monoclonal mixed type (type II), and polyclonal mixed type (type III). 2, type I cryoglobulinemia often occurs in multiple myeloma, Waldenstron macroglobulinemia, lymphoma and so on. Generally, symptoms are manifested only in the late stage of the disease when the cryoglobulin content reaches 5 to 30 g/L. Clinically occurring Raynaud's phenomenon, thrombosis, ulcers, gangrene, etc., are the result of high viscosity and fouling caused by the presence of cryoglobulin deposits in the blood vessels. 3, type II cryoglobulinemia mainly found in chronic lymphocytic leukemia, lymphoma, Sjogren syndrome and rheumatoid arthritis, sometimes seen in multiple bone marrow and macroglobulinemia. Its clinical manifestations such as vasculitis, vascular purpura, glomerulonephritis and immune complexes are associated with an increase in type II cryoglobulin. 4, type III is specific to 30%, can also be found in SLE, Sjogren syndrome, rheumatoid arthritis, hemolytic anemia, lymphoma and a variety of infections (such as syphilis, leprosy, trypanosomiasis, subacute bacteria Endocarditis, nephritis after streptococcal infection, infectious mononucleosis, etc.). Its clinical manifestations are also related to the inflammatory effects caused by immune complexes. 5, a large number of cryoglobulin increased in cryoglobulinemia, multiple myeloma. 6, a small amount of cryoglobulin increased in chronic lymphocytic leukemia, kala-azar, renal insufficiency, systemic lupus erythematosus, rheumatic fever, bacterial endocarditis, lymphosarcoma, malaria, nodular polyarteritis. High results may be diseases: acute infection of the elderly, nephritis, cryoglobulinemia, renal damage, primary mixed cryoglobulinemia vasculitis, multiple myeloma considerations In order to prevent or reduce the loss of cryoglobulin, the syringe and the test tube should be pre-warmed first, and then the blood sample is placed at 37 ° C for 2 h to allow the blood to coagulate and then separate. Inspection process Immediately after venous blood collection, the test method is a method for measuring cold fibrinogen. Not suitable for the crowd There are no special taboos. Adverse reactions and risks No relevant information.

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