Aspartate aminotransferase (AST)

Aspartate aminotransferase (AST), formerly known as aspartate aminotransferase (GOT). AST (GOT) is present in the myocardium, skeletal muscle, and liver, with the highest myocardial content and the liver. GOT has two isoenzymes, which are called s-GOT in the cytoplasm. It is called m-GOT in the mitochondria. The GOT isoenzyme assay helps to understand the degree of tissue damage, myocardial, liver and kidney lesions. . s-GOT is elevated; m-GOT can be measured in serum when tissue is damaged. In myocardial infarction, m-GOT rises prior to s-GOT. Basic Information Specialist classification: cardiovascular examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Reduced in the central nervous system diseases. Normal value: Aspartate aminotransferase (colorimetric method): 8-28 U/L Aspartate aminotransferase (continuous monitoring penalty? -20U/L Above normal: Increased in myocardial infarction, liver disease (liver cancer, cirrhosis, chronic hepatitis, drug-induced hepatitis, hepatocyte necrosis), biliary tract disease, endocrine disease, acute pancreatitis, pulmonary infarction, hemolytic disease, drug poisoning, leukemia. negative: Positive: Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. Normal value Colorimetric method 8 ~ 28U / L; Continuous monitoring method 8 ~ 20U / L. Clinical significance Abnormal result Increased: seen in myocardial infarction, liver disease (liver cancer, cirrhosis, chronic hepatitis, drug-induced hepatitis, hepatocyte necrosis), biliary tract disease, endocrine disease, acute pancreatitis, pulmonary infarction, hemolytic disease, drug poisoning, leukemia. Reduced: seen in central nervous system diseases. Clinically, it is often used as an auxiliary test for myocardial infarction and myocarditis. When alanine aminotransferase (ALT) is significantly elevated and the ratio of AST/ALT is >1, it suggests damage to the liver parenchyma. This is the most common cause of alanine aminotransferase, abbreviated as alanine aminotransferase. For patients with acute and chronic viral hepatitis, the aspartate aminotransferase can be increased, but the increase is not proportional to the degree of liver damage. The level of the aspartate aminotransferase should not be used to judge the severity of the disease. Toxic hepatitis A variety of drugs and chemical agents, such as erythromycin, isoniazid, phenylbutazone, etc. can cause aspartate aminotransferase to increase, after stopping the drug, the aspartate aminotransferase quickly returned to normal. Need to check the crowd Patients with cardiopulmonary dysfunction. High results may be diseases: elderly patients with viral hepatitis, alcoholic heart disease in the elderly Preparation before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the physical examination, fasting should be done to avoid affecting the detection of indicators such as blood glucose in the second sky. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection; guests with a history of fainting, please explain in advance, we will make special arrangements. Requirements for inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Not suitable for people: There is no inappropriate crowd. Inspection process Aspartic acid and α-ketoglutaric acid form oxaloacetate and L-glutamic acid under the action of AST. Oxaloacetate forms malic acid under the action of malate dehydrogenase, and NADH is oxidized to NAD+, and the rate of decrease in absorbance can be monitored at 340 nm to calculate AST activity. Not suitable for the crowd There is no inappropriate crowd. Adverse reactions and risks no.

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