tear beta2-microglobulin

β2-MG is produced by B lymphocytes and T lymphocytes and may be involved in humoral immune function. When the histocompatibility complex (MHC) is transported to the cell surface and expressed by cells, β2-MG must be present. The β2-MG of tears is mainly produced by lacrimal glands and conjunctival lymphocytes, and is withdrawn from the cleft palate and lacrimal passage with tears. Basic Information Specialist Category: Ophthalmology Classification: Biochemical examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: The content of severe SS lacrimal gland tissue was relatively reduced when scarred. Normal value: Tear β2-microglobulin: 7.10-139.88mg/L Above normal: In the early and mid-term SS and superficial keratitis, the content of β2-MG increased; the levels of β2-MG and CEA in the eye malignant tumor were significantly increased. negative: Positive: Tips: Avoid using certain eye drops for a long time. Normal value (10.54 ± 3.44) mg / L. Clinical significance Abnormal results: In the early and mid-term SS and superficial keratitis, the content of β2-MG increased, but the content of severe SS lacrimal gland tissue decreased. The levels of β2-MG and CEA in the eye malignant tumors were significantly increased, and the positive rate of elevation was also significantly higher than that of the serum. The two indexes of tears decreased to normal after recurrence, and those with recurrence increased. Tear and serum β2-MG, CEA combined with clinical can be used as a reliable auxiliary diagnosis and follow-up method for ocular malignant tumors, which has certain clinical application value. Need to check the crowd: Patients with eye diseases. High results may be diseases: precautions for keratitis Inappropriate people: generally no special population. Forbidden before examination: Long-term use of certain eye drops, such as vasoconstrictive eye drops (containing naphthalene-sensitive ingredients), can easily form dry eye disease. Long-term eye cleansing fluid that destroys the natural formation of the tear film. Requirements for inspection: Possible eye diseases may be stimulated during the examination, and the doctors should be prepared to endure certain stimuli. Inspection process The doctor will take a special filter paper, and fold it at one end, and gently put it into the middle and outer 1/3 junction of the lower jaw of the subject. There is no pain in this test, but a small number of patients have mild discomfort but do not affect vision. The filter paper strip was placed in the conjunctival sac and removed five minutes later to measure the wet length. It is generally considered to be 10-15 mm normal, <10 mm is low secretion, and <5m is dry eye. In the absence of ocular surface anesthesia, the secretion function of the main lacrimal gland was tested; after the anesthesia, the secretory function of the lacrimal gland (basal secretion) was detected, and the observation time was 5 min. Not suitable for the crowd no. Adverse reactions and risks no.

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