Dedifferentiated chondrosarcoma

Redifferentiated chondrosarcoma can be seen in cases of relapse and metastasis, as well as in primary tumors with different malignant grades. In central chondrosarcoma, the progression from grade Ⅰ central chondrosarcoma to grade Ⅱ central chondrosarcoma is rare, even if it occurs slowly. Grade Ⅰ central chondrosarcoma can maintain its recurrence after many relapses and years of course The degree of malignancy does not change. The progression from Grade II central chondrosarcoma to Grade III central chondrosarcoma can be rapid and uncommon. Sometimes a grade I or II central chondrosarcoma can produce a more malignant tumor, histologically malignant fibrous histiocytoma, fibrosarcoma, osteosarcoma, and angiosarcoma. These tumors are defined as "redifferentiated chondrosarcomas". In 15% of cases of dedifferentiated chondrosarcoma, the patients are older than those with central chondrosarcoma, generally after age 50.

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