Congenital thymic hypoplasia

Congenital thymic hypoplasia is also called DiGeorge syndrome or the 3rd and 4th pair of pharyngeal sac syndrome. It is a congenital immune deficiency caused by abnormal development of the pharyngeal sac in the first to sixth pairs of embryos. From 6 to 10 weeks of the embryo, the thymus, parathyroid glands, part of the face, aortic arch, and cardiac tuberculosis develop from the cellular components of the first to sixth pair of pharynx. By the 12th week of gestation, the thymus migrates to the chest. Previously, if these embryonic tissues were abnormally developed, it would cause the symptoms. The disease is sporadic, so it is speculated that it is not caused by genetic defects, it may be caused by abnormal embryonic environment, such as maternal alcoholism may be one of the causative factors. Pathological examination showed thymus and thyroid deficiency or hypoplasia. There were no gender differences in the patients.

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