Variant erythema keratosis

Variable erythrokeratoderma (variable erythrokeratoderma), also known as erythrokeratodermia figurata variabilis or Mendes dacosta type erythrokeratodermia, is an autosomal dominant inheritance. The pathogenesis is caused by a mutation encoding the alpha; -4 gap junction protein (connexin 31), and its variant gene is located in the chromosome 1p34-p35 region. Most of them develop symptoms shortly after birth and improve with age. They can resolve after menopause, but the condition worsens during pregnancy. Cold, hot, wind stimuli and emotional excitement can be exacerbating factors. Skin lesions are more common in the extremities of the extremities, arms and face, and some patients have palmar plantar keratosis.

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