Pediatric neurofibromatosis

Pediatric neurofibromatosis is one of the most common syndromes in neurocutaneous syndrome, and is a disease of dysplasia of tissues and organs originating from the ectoderm. The etiology is unknown at present, and may be related to some mutations in early embryonic development. Often manifested as nerve, skin, and eye abnormalities, and sometimes spread to mesoderm or endoderm developing organs. Due to the different organs and systems involved, the clinical manifestations are diverse. There are currently more than 40 such diseases, but only three are common, namely neurofibroma, nodular sclerosis, and cerebral facial hemangioma (Sturge-Weber syndrome). These diseases are mostly autosomal dominant, with a high, incomplete penetrance.

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