Cytokeratin 19 Fragment Antigen (CYFRA21-1)

Cytokeratin 19 fragment antigen (CYFRA21-1) is a new tumor marker for detecting lung cancer, especially for the diagnosis of non-small cell lung cancer. Basic Information Specialist classification: Oncology examination classification: immune examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Serum ≦ 3.3 ng / ml. Positive: 1. The positive detection rate of various types of non-small cell lung cancer is 70%-85%, and the level is positively correlated with the clinical stage of the tumor. 2. The sensitivity to the diagnosis of various types of lung cancer is squamous cell carcinoma > adenocarcinoma > large cell carcinoma > small cell carcinoma. 3. It can be used as an effective indicator to track early recurrence after lung cancer surgery and radiotherapy and chemotherapy. 4. For other tumors, such as head and neck, breast, cervix, bladder, digestive tract tumors have a certain positive rate. Tips: Immunohistochemical staining often shows spotted false positive reactions on the slices, which should be noted. Some non-epithelial tumor tissues (leiomyosarcoma) are positively expressed and should be noted at the time of diagnosis. Normal value Serum ≦ 3.3 ng / ml. Clinical significance 1. The positive detection rate of various types of non-small cell lung cancer is 70%-85%, and the level is positively correlated with the clinical stage of the tumor. 2. The sensitivity to the diagnosis of various types of lung cancer is squamous cell carcinoma > adenocarcinoma > large cell carcinoma > small cell carcinoma. 3. It can be used as an effective indicator to track early recurrence after lung cancer surgery and radiotherapy and chemotherapy. 4. For other tumors, such as head and neck, breast, cervix, bladder, digestive tract tumors have a certain positive rate. Positive results may be diseases: cervical cancer, lung cancer, thymic cancer, small cell thymoma, bladder cancer 1. Immunohistochemical staining often shows spotted false positive reactions on the sections, which should be noted. 2. Some non-epithelial tumor tissues (leiomyosarcoma) are positively expressed and should be noted at the time of diagnosis. Inspection process The free part of the small molecule is adsorbed by the surface activity of the activated carbon. For example, a layer of dextran is coated on the surface of the activated carbon to make a mesh having a certain pore diameter on the surface, thereby allowing small molecules of free antigen or hapten to escape and being adsorbed, while the macromolecular complex is excluded. After the antigen and the antibody are reacted, dextran-activated carbon is added, and the mixture is allowed to stand for 5 to 10 minutes, so that the free antigen is adsorbed on the activated carbon particles, and the particles are precipitated by centrifugation, and the supernatant contains the labeled antigen, and after separation of B and F, The radioactivity can be measured. There are two types of measuring instruments: a liquid scintillation counter (measuring beta rays) and a crystal scintillation counter (measuring gamma rays). The unit of counting is the number of electrical pulses output by the detector in units of cpm (number of pulses/min). For the determination, a standard curve is required, and the different concentrations of the standard antigen are plotted on the abscissa, and the corresponding radioactivity measured is plotted on the ordinate. The radioactivity may be optionally B or F, and the calculated values ​​B/B+F, B/F or B/B0 may also be used. Specimens should be measured in duplicate, the average value taken, and the corresponding antigen concentration to be detected on the standard curve. Not suitable for the crowd There is no inappropriate crowd. Adverse reactions and risks It is a safe check and is harmless to the body.

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