fetal pancreatic acinar protein

Fetal pancreatic acinar protein (FAP) is a fetal pancreatic specific antigen with the highest secretion at 20 weeks of gestation and low adult organ content. The human fetal pancreatic vesicle protein has a molecular weight of 60 kD and 110 kD, and a monoclonal anti-J28 antibody recognizes a 110 kD FAP. FAP is a glycoprotein that binds to ConA and is specific for pancreatic acinar. Highly expressed around pancreatic cancer, but low in chronic pancreatitis. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether women are fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Normal person inhibition rate Positive: In patients with pancreatic cancer, the inhibition rate is >30% positive. Tips: When the sample concentration exceeds 400μg/L, it is best to dilute it before testing. Normal value Normal human inhibition rate <10% (RIA results are expressed as percentage inhibition rate). Clinical significance In patients with pancreatic cancer, the inhibition rate is >30% positive. Of the 50 patients with pancreatic cancer, 49 had an inhibition rate >10%, of which 20 were between 10% and 30% and 29 were >30%. For example, the 10% inhibition rate is the upper limit of normal, and the positive rate of pancreatic cancer is 86%, but the specificity is only 66%. If the 30% inhibition rate is used as a criterion, the positive rate of pancreatic cancer decreased to 51%, but the specificity increased to 95%. At this time, most benign diseases and non-pancreatic tumor sera were negative. Positive results may be diseases: pancreatic cancer, chronic pancreatitis precautions (1) The measurable range of this method is 1 ~ 400μg / L, but the most sensitive range is 1 ~ 100μg / L. When the sample concentration exceeds 400 μg/L, it is best to dilute it before testing. (2) When the second antibody is added and incubated, the precipitate is centrifuged until the naked eye sees a significant flocculent precipitate, otherwise the incubation time or the amount of the second antibody should be prolonged. Inspection process The measurable range is from 1 to 400 μg/L, but the most sensitive range is from 1 to 100 μg/L. When the concentration of the sample exceeds 400 μg / L, it is best to dilute and then test. When the second antibody is added and incubated, the precipitate is centrifuged until the naked eye sees a clear flocculent precipitate. Otherwise, the incubation time should be extended or the second should be increased. The amount of antibody. Not suitable for the crowd There is no inappropriate crowd. Adverse reactions and risks It is a safe check and is harmless to the body.

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