Prolactin (PRL) stimulation test

The prolactin (PRL) secretion inhibition test is a test method for measuring the PRL basic value under fasting and resting state, and then taking the bed during oral levodopa test and taking blood again for 3 hours after taking the drug. Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Disabling drugs that affect prolactin secretion. Normal value A normal person has a peak after 90 minutes of administration, which is more than 3 times more than the basal value or a peak/base ratio of >2.5. The response of patients with functional hyperprolactinemia is similar to that of normal people. Clinical significance Patients with PRL tumors had no response or delayed response, with a base/base ratio <1.5. Abnormal results: PRL tumors are common in female patients and occur mostly in the 20 to 40 years old. Female PRL tumors often present as galactorrhea-menopausal syndrome. The tumor size was positively correlated with the patient's serum PRL concentration. The larger the tumor, the higher the PRL level and the more obvious the symptoms. 1, female PRL tumors are mostly microadenomas, seen in young people aged 20 to 30. The typical symptom is amenorrhea-milk-infertility triad. Secondary amenorrhea is more common, accounting for about 90%. Milk spill is the main manifestation of this disease, mostly for touch lactation, accounting for 50% to 90%. Sexual dysfunction accounts for about 60%, complaining of decreased or absent libido, loss of sex, lack of orgasm, and sputum pain. Other symptoms of hypogonadism are shortened menstruation, rare or excessive menstrual flow, delayed menstruation, and infertility. In addition, due to serum reduction caused by breast atrophy, pubic hair loss, vulvar atrophy, vaginal secretions and other symptoms. 2, male PRL tumor male prolactinoma diagnosis is generally larger, often developed on the saddle, but relatively rare. The main symptoms of sexual dysfunction, accounting for about 83%, can be complete or partial. If the degree of libido declines, impotence, male infertility and the number of sperm decreased. 3, tumor compression group is more common in large or advanced PRL tumors and other types of pituitary adenoma, hypothalamic and parasagittal tumors due to the huge expansion of the tumor to the saddle to block PIF caused by high PRL. The most common local compression symptoms are headaches and visual abnormalities. The cause of headache is mostly increased intracranial pressure caused by large adenoma, which may be accompanied by nausea and vomiting. The incidence of headache in male PRL tumor patients is higher than that in female patients, about 63%. Some PRL microadenomas may have headaches (50%) although the lesions are not obvious, and the reason is not clear. People who need to be examined: Suspected amenorrhea, galactorrhea, breast atrophy, pubic hair loss, loss of libido, impotence and other symptoms of prolactinoma-related symptoms. High results may be diseases: hyperprolactinemia, amenorrhea, breast cancer, prolactinoma, gynecomastia Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Disabling drugs that affect prolactin secretion. Requirements for inspection: Actively cooperate with the doctor's request. Pay attention to the early morning fasting under the basic state, first blood test to measure the basic value of PRL. Note that the test should be performed in strict accordance with the prescribed time interval. Inspection process method: 1 In the morning, the fasting under the basic state, first take the blood to measure the basic value of PRL. 2 Metoclopramide (MfF) 10 mg intramuscularly, blood was taken at 30, 6, 90 and 120 minutes after administration to check PRL. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks No obvious complications and harms.

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