Corticotropin-releasing hormone (CRH) stimulation test

The cortisol releasing hormone (CRH) stimulation test is to check whether the secretion of cortisol-releasing hormone is normal, to determine whether the person to be examined has adrenal insufficiency, hypothalamic lesions, primary adrenal insufficiency, and ectopic ACTH secretion. Sign the lesion. Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Adrenal cortex hormones or drugs that affect the secretion function of the adrenal gland and pituitary gland are stopped 2 weeks before the test. Normal value ACTH secretion can increase in normal people in 15 minutes, and the peak of cortisol is 30 to 60 minutes. Clinical significance Abnormal results: Pituitary ACTH secreting cells are destroyed. Patients with secondary adrenal insufficiency have no response to CRH stimulation test; patients with hypothalamic lesions have delayed response; primary adrenal insufficiency increases ACTH basal value and stimulates CRH The reaction is too strong; in the ectopic ACTH secretion syndrome, the tumor spontaneously secretes ACTH, which may not respond to this test. People who need to be examined: suspected adrenal cortical hypofunction, hypothalamic lesions, primary adrenal insufficiency, ectopic ACTH secretion syndrome and other symptoms. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. One part of the patient developed facial flushing after injection, or shortness of breath, pulse increase and hypotension. 2 2 weeks before the test, the drug of adrenal cortex hormone or the function of adrenal gland and pituitary gland secretion was stopped. Inspection process method: 1 In the morning, the blood was taken on an empty stomach and the ACTH and cortisol were taken, and then CRH was administered at a dose of 1 μg/kg body weight. 2 At 15, 30, 60 and 90 minutes after the injection, blood was taken for ACTH and cortisol. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.

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