Perchlorate release test

The perchlorate release test is a normal condition in which iodine is taken up from the blood by the thyroid in the form of ions, and is rapidly organicized after entering the thyroid gland. First, it is oxidized to an iodine molecule by the action of peroxidase, and the iodine molecule is further combined with tyrosine to form organic iodine under the action of iodinase. Therefore, there is little iodine in the form of ions in normal thyroid tissue. When peroxidase is deficient or dysfunctional, iodide ions entering the thyroid gland cannot be oxidized, and a large amount of ion iodine exists in the thyroid gland. Perchlorate prevents the thyroid from taking up iodine and promotes the release of iodide from the thyroid gland. After taking perchlorate, iodide ions are released from the thyroid gland into the blood. Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Normal value The release rate is ≤10%, indicating that the iodine oxidation process is normal; the release rate is >10% and ≤50%, suggesting that the iodine organicization is mildly disordered; the release rate is >50%, suggesting that the iodine is organically severely impaired. Clinical significance This test determines the iodine melanogenesis in the thyroid gland by measuring the change in 131 iodine rate before and after taking perchlorate. Abnormal results: Hypothyroidism, referred to as hypothyroidism. It is caused by insufficient synthesis or secretion of thyroid hormone. According to the age of onset, it can be divided into three types, namely, small illness (cretinism), juvenile and adult hypothyroidism (severely called mucinous edema), and the clinical manifestations may be different. People who need to be examined: patients with impaired thyroid dysfunction, such as hypothyroidism. High results may be diseases: precautions for postpartum thyroiditis Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. This test is taking anti-thyroid drugs (such as thiourea, tazobactam, PAS, D860, etc.), and patients with hyperthyroidism after taking I can also be positive. Inspection process Oral 131 iodine (usage and dosage with 131 iodine test of thyroid gland), measured 131 iodine rate of thyroid in 2h, and then oral potassium perchlorate (kClO4) 600mg, 1h or 2h, measured thyroid 131 iodine rate again. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.

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