Dexamethasone inhibits aldosterone test

Dexamethasone inhibits the aldosterone test by the following principle. In the primary aldosteronism, there is a special type called glucocorticoid-inhibiting aldosteronism. Has the following characteristics: (1) clinical manifestations are the same as classic primary aldosteronism; (2) patients are young, most occur before the age of 20; (3) have a tendency to have familial sputum; (4) pathology The basis is bilateral adrenal hyperplasia; (5) ACTH dependent. Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Normal value The blood aldosterone is below 138.5 pmol/L. Clinical significance The main basis for the diagnosis of this test is the dexamethasone inhibition test. Dexamethasone can restore the renin-angiotensin-aldosterone system of the patient to normal, and the clinical symptoms disappear. Abnormal results There are three types of clinical symptoms of aldosteronism: 1. Hypertensive patients have high blood pressure, and appear earlier, often appear in about 4 years before the onset of hypokalemia. Generally, it is moderately elevated, and the increase in diastolic blood pressure is more obvious. 2. Neuromuscular dysfunction (1) Neuromuscular weakness and paralysis Generally speaking, the lower the blood potassium, the heavier the myopathy. Tiredness, coldness, tension, diarrhea, sweating, and loss of potassium-diuretic diuretics (such as hydrochlorothiazide, furosemide) can be induced. It is often found that the lower limbs cannot move autonomously when they wake up in the morning. The severity of the attack varies, and the severe one can affect the upper limbs, sometimes involving the respiratory muscles. Cranial nerve innervation muscles are generally unaffected. Bilateral flaccid convulsions at the time of onset. (2) Paroxysmal hand, foot and ankle and muscle spasm were found in about 1/3 of patients, with beam arm compression sign (Trousseau sign) and facial nerve attack sign (Chvostek sign). It can last for days to weeks. Can appear alternately with paroxysmal paralysis. 3. Potassium deficiency nephropathy and pyelonephritis Patients who need to be examined have clinical symptoms of hyperaldosteronism such as hypertension, neuromuscular dysfunction, potassium loss nephropathy and pyelonephritis. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process [method] Oral dexamethasone 1mg at midnight, oral administration of 0.5mg at 6 o'clock in the morning, standing for 2 hours, blood test aldosterone <138.5pmol / L can be diagnosed. [Result analysis] If the patient's blood aldosterone is not inhibited to 138.5 pmol / L after taking dexamethasone, glucocorticoid-inhibiting aldosteronism can be ruled out. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks No related complications and hazards.

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