Plasma 17-hydroxyprogesterone

17α-hydoxyprogesterone (17α-OHP) is produced by the adrenal cortex and gonads, and its progesterone activity is very low. 17α-OHP is 21-hydroxylated to form the precursor compound S (CpS) of cortisol. 17α-OHP has a circadian rhythm change consistent with adrenal cortisol. The concentration of 17α-OHP in adult women of childbearing age varies with the menstrual cycle, and the luteal phase is higher than the follicular phase. The fetus, placenta and adrenal glands produce a large amount of 17α-OHP during pregnancy. The concentration of 17α-OHP increased sharply after 32 weeks of gestation until the delivery period, and 17α-OHP was also present in cord blood of newborns. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: The use of the drug clomiphene can increase the progesterone test results, the use of ampicillin, oral contraceptives can reduce progesterone levels. Normal value The follicular phase of women of childbearing age is 0.1-0.8 ng/ml, the luteal phase is 0.27-2.9 ng/ml, and the third trimester is 2-12 ng/ml. Males range from 0.31 to 2.13 ng/ml. Clinical significance The concentration of 17α-OH-P in patients with congenital adrenal hyperplasia lacking 21-hydroxylase was significantly increased, and the increase in 17α-OH-P was less in the absence of 11-hydroxylase. About 6% of adult hairy women have varying degrees of 21-hydroxylase deficiency. The 17P concentration in this type of delayed-type deficiency often exceeds the high limit of 0.9 NG/ML in the follicular phase. The 17α-OH-P assay was also used to analyze common acne, male baldness and some unexplained infertility in men and women. Precautions The use of the drug clomiphene can increase the progesterone test results, using ampicillin, oral contraceptives can reduce progesterone levels. Inspection process Take appropriate plasma and send it for inspection. Not suitable for the crowd People who have used ampicillin or oral contraceptives before the test. Adverse reactions and risks Risk of infection: If you use an unclean needle, you may be at risk of infection.

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