hemoglobin A2

Various hemoglobins have different isoelectric points and can carry different charges in buffers of a certain pH. It has a negative charge in alkaline buffer and is positively charged. Hb molecules with different charges in a certain electric field can move to the positive or negative electrode respectively, and the moving speed varies with the intensity of the charge of the Hb molecule, resulting in various zones-electrophoresis patterns. Various abnormal hemoglobin can be initially identified from the electropherogram, and the content is determined by photoelectric colorimetry or scanning. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Before you check, pay attention to rest and ban diet. Normal value 2.5% to 3.5% (about 1% under 1 year old). Clinical significance (1) Hemoglobin A2 increases beta-globin production anemia. (2) Reduction of hemoglobin A2 is seen in alpha and delta globin-producing anemia, severe iron deficiency anemia, and hereditary HbF syndrome. (3) Other hemoglobin A2 in megaloblastic anemia, certain unstable hemoglobinopathy, tumor and liver diseases can also be increased. High results may be diseases: anemia caused by hypothyroidism, iron deficiency anemia considerations (1) After electrophoresis, the hemoglobin zone is clear and tidy, and the distance between HbA and HbA2 is more than 6 mm. (2) If the electrophoretic zone of some abnormal Hb is close to the HbA2 zone, it may cause a false increase of HbA2. Inspection process Commonly used cellulose acetate membrane electrophoresis. Not suitable for the crowd No taboos. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.

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