Pulmonary histiocytosis

Histiocytosis is a rare group of unexplained diseases that was named by Lichtenstein in 1953. The disease mostly occurs in children, and its pathogenesis, clinical symptoms, and range of lesions vary widely, but the pathology has common pathological characteristics, that is, abnormal proliferation of tissue cells. This tissue cell has been confirmed to have the characteristics of Langerhans histocyte, so this disease is now also called Langerhans histiocytosis. Pulmonary Langerhans histiocytosis can be primary in the lungs or part of a systemic disease. Previously, the nomenclature for the disease was more confusing, with focal lesions referred to as eosinophilic granuloma, and systemic lesions referred to as letter-Siwe disease (Ley-Snow disease) and Hand-Schller-Christian disease (Han- Hsu-gram disease). In order to avoid confusion, the American Society of Histology and Cells proposed a new classification method for such diseases according to the condition of affected organs in 1997.

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