Nodular liquefied panniculitis

This disease is also called pancreatic subcutaneous nodular fat necrosis. It is clinically characterized by repeated redness and painful subcutaneous nodules, 0.5 to 5 cm in diameter. The skin lesions first occurred in the calf and later spread to the entire body. Some nodules may contain aseptic viscous substances after the softening period, and skin lesions may be accompanied by paroxysmal abdominal pain, polyarthritis (or joint pain), fever, and eosinophilia. The lesions spontaneously subsided without epidermal atrophy. Hansemann (1889) first found that nodular subcutaneous fat necrosis was associated with pancreatic disease. Blauvelt (1946) noted that nodular skin lesions of the calf can develop in acute pancreatitis.

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