Alpha-thalassemia in children

Alpha thalassaemia in children is a group of hemolytic anemia caused by the α-globin chain synthesis disorder due to the deletion or functional defect (point mutation) of the α-globin gene, which belongs to a type of thalassemia. Thalassemia is also known as "globin production disorder anemia", which is caused by the synthesis of one or more globin peptide chains being blocked or completely inhibited, resulting in an abnormal composition of Hb components and causing chronic hemolytic anemia. According to the different types of globin gene deletions or defects that cause the corresponding inhibition of the synthesis of globin, the thalassemia can be divided into α-thalassemia; β-thalassemia, δ-thalassemia, γ-thalassemia and Rare beta-thalassemia; the previous two types were common. All belong to autosomal incomplete dominant inheritance.

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