Synovitis, acne, impetigo, bone hypertrophy, osteomyelitis syndrome

Synovitis, acne, impetigo, bone hypertrophy, and osteomyelitis syndrome (synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome), referred to as SAPHO syndrome. SAPHO is an abbreviation of the following 5 English words, namely: synovitis, acne, pustulosis, hyperostosis, and osteomyelitis. SAPHO syndrome is a chronic disease that mainly affects the skin, bones, and joints. The disease mainly includes bone lesions and palmoplantar impetigo. Sasaki first described a case of clavicle aseptic hypertrophic osteitis with palmoplantar pustulosis in 1967, and more than 250 cases have been reported since then. In 1987, Charnot et al. Summarized, took the first letter of each lesion, proposed the name of SAPHO syndrome, and classified the bone and joint lesions of this syndrome into rheumatic manifestations (lumps, outbreaks, sweat glands) associated with acne. , Purulent), palm, plantar pustulosis, sternoclavicular hypertrophy and chronic recurrent osteomyelitis in four groups. All patients affected the sternum joint and caused aseptic osteoporosis osteitis. In 1987, French physician Charmot and others proposed to collectively refer to the damage of palmoplantar pustulosis, suppurative sweat glanditis, or severe acne with sternum and clavicle hypertrophy, chronic recurrent multifocal arthritis, and sacroiliitis. Its common feature is that skin lesions have aseptic pustules in a certain period, and bone lesions include aseptic osteitis, aseptic osteomyelitis, and arthritis. Kawdi et al. Noticed that similar inflammation cells infiltrated the skin, bone, and synovial tissue, and thought that the three lesions had a common cause. In the past ten years, although there have been more and more clinical reports, the related reports on its etiology and pathogenesis are almost blank. At present, the number of cases reported worldwide is less than 300. More than 80% of cases are concentrated in Europe, and the rest are in countries and regions such as North America, Japan, and Australia. No official report has been reported in China.

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