Motor neuron disease

Amyotrophic lateral sclerosis (ALS) had exactly the same meaning as motor neuron disease in the earlier period, and specifically refers to an independent disease with damage to the lower motor neuron followed by damage to the upper motor neuron. However, it was later discovered that there are two other variants, that is, only the upper motor neuron or the lower motor neuron is always involved in the course of the disease. So far, some literatures still use motor neuron disease to refer specifically to amyotrophic lateral sclerosis. Most scholars are accustomed to divide motor neuron disease into three types of amyotrophic lateral sclerosis, primary lateral sclerosis and spinal muscular atrophy according to different combinations of upper and lower motor neuron involvement. Recent studies suggest that amyotrophic lateral sclerosis has a common pathological basis with a variety of related diseases, including primary lateral sclerosis, ALS-dementia, ALS-related frontal dementia, progressive spinal muscular atrophy, multiple System atrophy and lewy body disease. Pathological examination found that these diseases also contained ubiquitin-positive inclusions and transparent clumped inclusions, but different clinical anatomy sites were damaged and various clinical combinations appeared.

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