Keratocyte differentiation

Gastrointestinal cancer (gastrointestinal carcinoma), colon and rectal cancer are the second most common primary tumors and the most common visceral tumors that metastasize to the skin. Most occur in the rectum, accounting for 11% to 19% of skin metastatic cancers in men and 1.3% to 9% in women. Colorectal cancer is usually found before skin metastases. Skin metastatic cancers from the gallbladder and bile ducts can be seen when the primary tumor is found, but can be as late as 40 years after the primary tumor is removed. Skin metastatic cancers from the stomach and pancreas usually occur before the primary tumor is found, usually from the stomach The sites of skin metastatic cancer are the abdominal wall, perineum and umbilicus. There are very few inflammatory cells infiltrating the sweat-free gland duct keratinocytes and so on around tumor cells, which is often a characteristic of metastatic skin tumors.

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