Serum hepatitis D antibody

Hepatitis D Virus (HDV) is a defective single-stranded negative-strand RNA virus with a diameter of 35 to 37 nm and a spherical shape. Its outer membrane is HBsAg and the core contains a specific hepatitis D virus antigen (HDAg). ) And viral RNA. During the maturation of HDV, HBsAg needs to be assembled into a complete virus particle with the help of HBsAg as the outer membrane protein. HDV itself cannot be infected, only those who are HBsAg positive. HDVAg is highly antigenic and can stimulate the body to produce IgM and IgG antibodies. These antibodies are non-neutralizing antibodies and have no protective effect on the body. HDV laboratory tests can use nucleic acid hybridization and PCR methods to detect its RNA, and ELISA and RIA methods can also be used to detect HDVAg, anti-HDV IgM, and anti-HDV total antibodies.

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