Platelet lifespan is shortened

Introduction Platelets are a fragment of blood cells and an atypical cell because they do not have a nucleus. So it is also an atypical cell. A shortened platelet life can cause thrombocytopenia.

Cause

Causes of shortened platelet life

Genetic defects or drug treatment result in a lack of activity of Bcl-xL, which indirectly leads to a shortened life span of platelets.

an examination

Related inspection

Blood routine

Examination of shortened platelet life

It can block the spleen's retention of platelets, increase platelet destruction or utilization, and be diluted. Severe thrombocytopenia, regardless of the cause, can cause typical bleeding. Multiple ecchymoses, most common in the lower leg; or small scattered ecchymoses in areas with minor trauma; mucosal bleeding (nasal bleeding, gastrointestinal and genitourinary tract and vaginal bleeding); and massive bleeding after surgery. Massive bleeding in the intestines and bleeding in the central nervous system can be life-threatening. However, thrombocytopenia does not manifest intra-tissue bleeding (such as deep visceral hematoma or joint hemorrhage) as secondary to coagulopathy.

Differential diagnosis

Differential diagnosis of confusing symptoms caused by shortened platelet life

1. Idiopathic (immune) thrombocytopenic purpura, a hemorrhagic disease without systemic disease, adult patients appear chronic, while children are often acute and self-limiting. Adult idiopathic (immune) thrombocytopenic purpura (ITP) is due to the production of an antibody (autoantibody) against structural platelet antigens; whereas in children with ITP, the synthesis of antibodies is stimulated by viral antigens. The antibody reacts with a viral antigen attached to the surface of the platelet.

2. Thrombocytopenia may result from insufficient platelet production, retention of platelets by the spleen, increased platelet destruction or utilization, and dilution. Severe thrombocytopenia, regardless of the cause, can cause typical bleeding. Multiple ecchymoses, most common in the lower leg; or small scattered ecchymoses in areas with minor trauma; mucosal bleeding (nasal bleeding, gastrointestinal and genitourinary tract and vaginal bleeding); and massive bleeding after surgery. Massive bleeding in the intestine and bleeding in the central nervous system can be life-threatening.

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