Decreased serum HDL-C levels

Introduction Hyperlipidemia is a systemic disease in which blood cholesterol (TC) and/or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low. Modern medicine calls it dyslipidemia. .

Cause

Causes of decreased serum HDL-C levels

The causes of hyperlipidemia can be basically divided into two categories, namely, primary hyperlipidemia and secondary hyperlipidemia.

Primary hyperlipidemia

1. Genetic factors: Genetics can cause hyperlipidemia through a variety of mechanisms, some of which may occur on cells, mainly due to defects in cell surface lipoprotein receptors and defects in certain enzymes in cells (such as lipoprotein lipase). Defects or deficiency) can also occur on the molecules of lipoproteins or apolipoproteins, mostly due to genetic defects.

2. Dietary factors: A significant proportion of patients with hyperlipoproteinemia are closely related to dietary factors.

an examination

Related inspection

Blood routine

Examination of serum HDL-C levels is reduced : blood tests.

Differential diagnosis

Serum HDL-C levels reduce confusing symptoms

Hyperlipidemia and hypertension

There are many factors affecting the increase of blood pressure. The peripheral resistance of blood vessels, the elasticity of arterial wall and the viscosity of blood are important factors for the formation of hypertension, and these three factors are directly related to hyperlipidemia.

The normal human endometrium is smooth and smooth, and the blood lipids will gradually deposit yellow atheroma under the intima of the blood vessels. The rupture, hemorrhage, narrowing of the lumen, increased blood flow resistance, and blood pressure increase; Increased, blood lipids in the intima of the arteries can cause hardening of the blood vessels, weakening the elasticity of the blood vessel wall, and raising blood pressure. When the blood fat is increased, the blood viscosity is increased, so that the blood flow resistance is increased, and the blood pressure is increased.

Hyperlipidemia can also reduce the sensitivity of antihypertensive drugs and increase the difficulty of antihypertensive treatment. Therefore, the treatment of hypertension should reduce blood lipids.

Relationship between hyperlipidemia and hyperglycemia

Many people with diabetes are associated with hyperlipidemia. Therefore, diabetes and hyperlipidemia are often referred to as sister diseases, and hyperlipidemia is considered to be a secondary disease of diabetes. According to statistics, about 40% of diabetic patients have lipid metabolism disorders. It is characterized by an increase in triglycerides and a decrease in high density lipoprotein. The reason for the increase in blood lipids caused by diabetes is that when the insulin is deficient in diabetics, the activity of lipase in the body is reduced, so it is easy to increase blood lipids. On the other hand, in addition to the disorder of glucose metabolism, diabetes itself is accompanied by disorders of fat, protein, water and dielectric. Free fatty acids are often mobilized from the fat store to increase the concentration of triglycerides and free fatty acids in the blood. On the other hand, people with type 2 diabetes eat too much and exercise less, which promotes the increase of lipid synthesis in the body, which is also the cause of the increase in blood lipids. Obesity with hyperlipidemia, due to the relative decrease in the number of insulin receptors, resulting in insulin resistance, easy to induce diabetes. Increased blood lipids are also prone to heart and cerebrovascular complications.

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