Vascular atrophic leukoplakia

Introduction 10%~30% of patients with systemic lupus erythematosus can see reticular leukoplakia, which is a manifestation of small vessel inflammation and circulatory disorder. It is the narrowing of the small arteriolar lumen of the limbs, the expansion of small veins, and the appearance of nets and branches on the skin surface. The erythema and purple blemishes often appear in cold conditions and may be associated with cryoglobulinemia and anticardiolipin antibodies. Occurs in the thighs, calves, hands, back of the feet, elbows, knees, if there is necrotizing vasculitis, often accompanied by purple spots, gangrene, ulcers. If the vascular disease is severe, skin lesions of the leukoplakia vasculitis may occur, manifested as blemishes accompanied by painful ulcers, and the ulcers healed to form atrophic scars with hypopigmentation and telangiectasia, ie, atrophic leukoplakia.

Cause

Causes of vascular atrophic leukoplakia

1. Neurological factors. Many patients are affected by various environmental stimuli and trauma. Emotional fluctuations, anxiety, nervousness, irritability, depression and other adverse stimuli are likely to cause disturbances in the body's physiological and biochemical reactions, and induce or aggravate the development of the disease. . Others think it is a psychosomatic disease.

2. Autoimmune factors. Many experts believe that it is an autoimmune disease and may be related to thyroid disease.

3, melanocyte self-destruction factors.

4. There is a relative lack of tyrosine and copper ions.

5. Genetic factors. Some people think that it is autosomal dominant inheritance, but it has not been agreed by everyone. Therefore, it can only be considered that heredity plays a certain role. If there are neuropsychiatric factors and autoimmunity, it is easy to develop.

6, trauma.

7, microcirculation obstacles. Because the microcirculation is blocked, nutrients cannot be delivered to the skin. Melanocytes do not grow normally and thus decolorize the skin.

According to the viewpoints of various theories, it is generally believed that the disease is an individual with genetic quality. Under the stimulation of various internal and external factors, it manifests as disorder of immune function, nerve, spirit and endocrine, metabolic function, etc., leading to inhibition of the enzyme system. Or the destruction of melanocytes or the process of melanosome formation or blackening, and finally to the loss of pigment.

Mental factors and neurochemical factors may play an important role in the pathogenesis.

an examination

Related inspection

General radiography examination angiography blood test

Examination of vascular atrophic leukoplakia

Although reticular leukoplakia is more common in systemic lupus erythematosus, it can also occur in other rheumatic diseases, such as nodular polyarteritis, dermatomyositis, mixed connective tissue disease and other chronic infectious diseases such as tuberculosis and syphilis. Sexual cardiovascular disease and arteriosclerosis, so reticular bluish is not a specific manifestation of patients with systemic lupus erythematosus.

Differential diagnosis

Symptoms of vascular atrophic leukoplakia

1. There is no need for good white spots, and there are many pigments deepening at the border. Discoid lupus erythematosus has discoid erythema. The erythema is covered with adhesive scales. It is better to apply to the face and ear, and the pigmentation loss occurs. The recovery period of the old rash.

2. The disease is the reduction or disappearance of melanocytes. Discoid lupus erythematosus is hyperkeratotic, the hair follicle is enlarged, there is horny plug, and the phlegm cells are increased in the upper part of the dermis.

Although reticular leukoplakia is more common in systemic lupus erythematosus, it can also occur in other rheumatic diseases, such as nodular polyarteritis, dermatomyositis, mixed connective tissue disease and other chronic infectious diseases such as tuberculosis and syphilis. Sexual cardiovascular disease and arteriosclerosis, so reticular bluish is not a specific manifestation of patients with systemic lupus erythematosus.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.