White matter demyelination

Introduction The normal myelin that has matured is destroyed, that is, the white matter demyelination disease. It mainly includes: multiple sclerosis, progressive multifocal leukoencephalopathy, acute sporadic encephalomyelitis, subacute sclerosing panencephalitis, central pontine myelinolysis, corpus callosum degeneration, subcortical arteriosclerotic encephalopathy and concentricity Round hardening, etc. Many diseases can occur in the white matter of the brain. The typical response of white matter to various noxious stimuli is demyelination, which can be secondary manifestations of neurological diseases such as infection, poisoning, degeneration, post-trauma, and lack of infarction.

Cause

There is a group of central nervous system demyelinating diseases that are still unclear. Therefore, the current classification of this group of diseases, according to their maturity when the disease is mature, can be divided into two major categories: 1 myelin normal development of demyelinating diseases such as multiple sclerosis, Progressive multifocal leukoencephalopathy, acute sporadic encephalomyelitis, etc.; 2 myelinating disorders such as spheroid cell type white matter dystrophy, metachromatic leukodystrophy, spongiform encephalopathy, etc.

an examination

Related inspection

Brain CT examination, brain MRI, EEG, brain function imaging

Multiple sclerosis is a demyelinating disease of the central nervous system caused by autoimmune disorders.

The main symptoms and signs of multiple sclerosis: more than 20-40 years old, and less than 10 years old and 50 years of age, the onset can be urgent. Expressed as:

(1) Psychiatric symptoms: such as irritability, strong crying, strong laughter, memory loss, etc.

(2) The structure of the dysarthria or the voice is different.

(3) Visual impairment.

(4) Feeling diminished or feeling abnormal.

(5) Physical activity is unfavorable or paralyzed.

(6) urinary dysfunction, impotence and so on. The disease has volatility, that is, the symptoms can be relieved by themselves after one attack or relieved after treatment, and can relapse after a period of time. However, each relapse can leave a certain degree of functional impairment, and the general trend is that the condition gradually deteriorates. The prognosis of this disease is generally not very bad, the average survival period after onset is 25-30 years.

Differential diagnosis

White matter atrophy: MRI shows that white matter atrophy is a symptom of clinical diagnosis of hereditary multiple cerebral infarction dementia.

Less white matter in the brain: Less white matter is a manifestation of malnutrition of the white matter.

Lean body white matter: white matter sparse hair occurs in people over 50 years old, common in dementia and cerebrovascular patients. CT features manifested as bilateral white matter symmetry low density lesions, or complicated with cerebral infarction, cerebral hemorrhage and brain atrophy.

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