Male precocious puberty

Introduction Precociouspuberty refers to the premature development of puberty. It is generally determined that boys who develop puberty before the age of 9 can be divided into two types: true (also known as central complete) precocious puberty and pseudo (also known as peripheral incomplete) precocious puberty. True precocious puberty refers to the hypothalamic-pituitary-gonadal axis being inappropriately prematurely active, leading to premature puberty development, which is the same as normal developmental period. The second sexual characteristic is consistent with genetic gender, can produce sperm or egg, and has fertility. ability.

Cause

Etiology classification

(a) true precocious puberty

1. Idiopathic precocious puberty.

2. Neurogenic precocious puberty.

3. Bone fibrous dysplasia.

4. Primary hypothyroidism.

(two) pseudo precocious puberty

1. Gonadal tumors.

2. Adrenal cortical tumors.

3. Hormone intake.

an examination

Hypothalamic pituitary, gonad and adrenal organic lesions must be excluded based on detailed clinical data and necessary laboratory tests. Laboratory tests should first determine whether precocious puberty is gonadotropin-dependent, and LH/FSH pulsatile secretion contributes to the identification of both. Imaging studies are mainly used to find tumors of the pituitary and gonads. If there is no organic disease, you can continue to follow the observation, but the possibility of LH receptor gene mutation should be excluded. The cause of gonadotropin independent precocious puberty is mainly in the gonads and adrenal glands. Due to the secretion of excessive amounts of gonadal hormones, it must be noted that some gonadal tumors, like the hypothalamic hamartoma, can synthesize and secrete gonadotropins.

Differential diagnosis

Differential diagnosis of male precocious puberty:

It is necessary to identify whether precocious puberty is gonadotropin-dependent, hypothalamic, pituitary, gonad and adrenal organic lesions. Precocious puberty in boys before the age of 9 is often prompted by organic lesions.

Hypothalamic pituitary, gonad and adrenal organic lesions must be excluded based on detailed clinical data and necessary laboratory tests. Laboratory tests should first determine whether precocious puberty is gonadotropin-dependent, and LH/FSH pulsatile secretion contributes to the identification of both. Imaging studies are mainly used to find tumors of the pituitary and gonads. If there is no organic disease, you can continue to follow the observation, but the possibility of LH receptor gene mutation should be excluded. The cause of gonadotropin independent precocious puberty is mainly in the gonads and adrenal glands. Due to the secretion of excessive amounts of gonadal hormones, it must be noted that some gonadal tumors, like the hypothalamic hamartoma, can synthesize and secrete gonadotropins.

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