Urinary porphyrinogen

Urinary biliary tract is a clinically less used test and is used for the differential diagnosis of hepatic porphyria. The gallbladder is unstable and can be easily converted into red and black bilirubin. Therefore, it is necessary to immediately send the fresh urine for inspection and immediately check it. The sensitivity of this method was 11 mg/L. Due to the large increase in urinary bilirubin in the onset of porphyria, the reaction is dark red, and the urine can be diluted 10 times before detection. Basic Information Specialist Category: Inspection Category: Urine/Kidney Function Test Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Hepatic porphyria, acute intermittent porphyria. Tips: Be sure to take fresh urine immediately for inspection and check immediately. Barbiturate, chlordiazepoxide, methionine, sulfa drugs, phenytoin, griseofulvin and estrogen are used with utmost care. Consult a doctor before use. Normal value negative. Clinical significance Abnormal result Hepatic porphyria disease, acute intermittent porphyria disease. Need to check the crowd Chronic liver disease patients with hematopoietic dysfunction. Positive results may be diseases: acute intermittent porphyria, hepatic porphyria syndrome considerations Requirements for inspection: The gallbladder is unstable and can be easily converted into red and black bilirubin. Therefore, it is necessary to immediately send the fresh urine for inspection and immediately check it. The sensitivity of this method was 11 mg/L. Due to the large increase in urinary bilirubin in the onset of porphyria, the reaction is dark red, and the urine can be diluted 10 times before detection. Preparation before inspection: Barbiturate, chlordiazepoxide, methionine, sulfa drugs, phenytoin, griseofulvin and estrogen are used with utmost care. Consult a doctor before use. Inspection process Porphyrin is an intermediate product of the synthesis process of hemoglobin, myoglobin, catalase, peroxidase and cytochrome in animals. Commonly used in the human body are coproporphyrin I, III, urinary porphyrin I, III, and protoporphyrin IX. In addition, there is a bile precursor, which is a porphyrin precursor, which is excreted in a large amount in the urine of a certain porphyrin patient. The urine color is normal, but after the urine is left in the sun for a few hours, the urine color deepens and turns reddish brown, which is the result of the biliary porphyrin becoming urinary porphyrin. All kinds of porphyrins are colored substances, and under the ultraviolet light of the special filter, they all show red fluorescence, so they can be quantified by fluorescent colorimetry. The coproporphyrin is dissolved in ether and the urinary porphyrin is insoluble, which is convenient for separation. Various porphyrins have different absorption bands in the spectroscopic spectrum. Not suitable for the crowd Not suitable for the crowd: there is no inappropriate crowd. Adverse reactions and risks No.

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