Anti-endometrial antibody (EMAb)

The target antigen for anti-endometrial antibodies is the endometrial glandular epithelial hormone-dependent protein. Binding of the EMAb to the target antigen can interfere with the implantation of the fertilized egg, resulting in infertility. Clinically, ELISA and immunofluorescence methods are commonly used. Anti-endometrial antibodies (EMAb) are autoantibodies that target the endometrium as a target antigen and cause a series of immune responses. It has been reported that the positive rate of anti-endometrial antibodies in the blood of endometriosis and infertile women is significantly higher than that of normal controls. Among the serum of endometriosis, the detection rate of EMAb is up to 70%-80%. Basic Information Specialist classification: gynecological examination classification: blood examination Applicable gender: whether women are fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Normal: ELISA, immunofluorescence; negative. Positive: Endometriosis (positive rate: 60% to 82%), unexplained infertility or habitual abortion women (positive rate: 30% to 40%). Tips: After 8 pm on the day before the medical examination, you should start fasting for 12 hours. Normal value ELISA method, immunofluorescence method: negative. Clinical significance Abnormal results are positive: Endometriosis (positive rate 60% to 82%), unexplained infertility or habitual abortion women (positive rate 30% to 40%). Need to check the crowd: unexplained infertility, habitual abortion, auxiliary diagnosis of endometriosis. Positive results may be diseases: menstrual disorders, infertility, immune infertility, endometriosis, serum anti-sperm antibody-positive infertility precautions Inappropriate people: generally no special population. Forbidden before examination: Please inform the doctor about the recent medication and special physiological changes before the test. 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. Requirements for examination: When taking blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection. Note: There is a low level of EMAb in the serum of a very small number of healthy reproductive women, which may be related to the reversal of the seminal blood flow into the abdominal cavity. Inspection process ELISA method is a highly sensitive test technique that combines the specific reaction of antigen and antibody with the efficient catalytic action of enzyme on substrate based on immunological reaction. The reaction of the antigen and the antibody is carried out in a well of a solid phase carrier, a polystyrene microtiter plate, and after each reagent is added, the excess free reactant can be removed by washing to ensure the specificity of the test result. stability. Not suitable for the crowd There are no special taboos. Adverse reactions and risks There are no related complications and hazards.

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