Anti-acetylcholine receptor antibody (anti-AchR)

Anti-acetylcholine receptor antibodies can cause neurotransmitter-to-muscle signaling disorders, leading to skeletal muscle weakness, namely myasthenia gravis. Severe sputum weakness (MG) is a neuromuscular disease characterized by muscle weakness and fatigue, with an incidence rate of 1/20,000 to 1/30,000. In 1973, Patr'ick and Lindstrom were first experimentally autoimmune. An antibody against acetylcholine receptor (AChR-Ab) was detected in animals with myasthenia gravis (EAMG). Basic Information Specialist classification: neurological examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Normal: ELISA. (ELISA): negative or less than 0.03 nmol/L. Positive: Abnormal results: increased or positive. Need to check the crowd: patients with myasthenia gravis, biliary cirrhosis, epilepsy, myotonic dystrophy. Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. Normal value Enzyme-linked immunosorbent assay (ELISA). Negative or less than 0.03 nmol/L. Clinical significance Abnormal results are increased or positive. Need to check patients with myasthenia gravis, biliary cirrhosis, epilepsy, myotonic dystrophy and other patients. Positive results may be diseases: myasthenia gravis, myotonic dystrophy, biliary cirrhosis Forbidden before examination: Please inform the doctor about the recent medication and special physiological changes before the test. 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. Requirements for examination: When taking blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection. Inspection process The basis of ELISA is the immobilization of antigens or antibodies and the enzymatic labeling of antigens or antibodies. The antigen or antibody bound to the surface of the solid support retains its immunological activity, and the enzyme-labeled antigen or antibody retains both its immunological activity and the activity of the enzyme. At the time of measurement, the test specimen (the antibody or antigen in which it is measured) reacts with an antigen or antibody on the surface of the solid phase carrier. The antigen-antibody complex formed on the solid support is separated from other substances in the liquid by washing. Further, an enzyme-labeled antigen or antibody is added, and is also bound to the solid phase carrier by a reaction. At this time, the amount of enzyme on the solid phase is proportional to the amount of the substance to be tested in the specimen. After the substrate of the enzyme reaction is added, the substrate is catalyzed by the enzyme to become a colored product, and the amount of the product is directly related to the amount of the test substance in the sample, so that qualitative or quantitative analysis can be performed according to the depth of the color. Due to the high catalytic efficiency of the enzyme, the result of the immune reaction is indirectly amplified, and the measurement method achieves high sensitivity. ELISA can be used to determine antigens and can also be used to determine antibodies. Not suitable for the crowd Abnormal people: generally no special population. Adverse reactions and risks No special complications or hazards.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.