Anti-Saline Extractable Nuclear Antigen (ENA) Antibody

Anti-ENA, also known as anti-extractable antigen (ENA) antibody, belongs to anti-histone antibody, including anti-Sm antibody, nRNP antibody, anti-SSA antibody, anti-SSB antibody, anti-Scl70 antibody, anti-Jo1 antibody and other autoantibodies. Different anti-ENA antibodies have star-like differences in various CTDs. Some autoantibodies are labeled antibodies or specific antibodies of certain diseases, which are of great significance for the diagnosis and differential diagnosis of autoimmune diseases. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Anti-Sm antibodies, like anti-dsDNA, are highly specific for SLE and are positive for anti-Sm regardless of active phase and can be used as a marker for SLE. Tips: morning fasting test, taboo after diet check. Normal value Immunoblotting was negative. Convection immunoelectrophoresis was negative. Clinical significance Abnormal results: normal people are negative. ENA antibody includes a variety of different antibodies, which is helpful for differential diagnosis of connective tissue diseases. For example, anti-Sm antibody is a marker antibody for lupus. Anti-Jo-1 antibody is generally found in polymyositis. Anti-SSA and anti-SSB antibodies are found in dry synthesis. The anti-Scl-70 antibody is found in scleroderma and the like. People in need of examination: patients with rheumatoid arthritis and systemic lupus erythematosus, as well as patients with related diseases and symptoms can be examined. Positive results may be diseases: precautions for rheumatoid arthritis in the elderly Taboo before the test: morning fasting test, taboo after diet check. Requirements for inspection: Mix well immediately after sampling to avoid air bubbles, which can cause hemolysis. Maintain at room temperature, optimal temperature, not refrigerated or frozen. Inspection process It has been detected by agar diffusion method or convective immunoelectrophoresis. In recent years, it has also been detected by immunoblotting. Anti-NNA antibodies mainly include seven antibodies against Sm and nRNP. mRNP or U1RNP antigens are seven proteins with different molecular weights (12-68KD). a complex that binds to U1RNA (U is a uracil nucleotide); and Sm is a complex of the same seven proteins with U2, U1, U4, U5, and U6 RNA; the positive rate of anti-Sm antibody in SLE is 20%. ~25%, a labeled antibody to SLE, often associated with anti-ds-DNA antibodies, has nothing to do with disease activity, and can be used as a reference for retrospective diagnosis; anti-U1RNP antibodies can occur in a variety of connective tissue diseases, High-efficiency, in addition to SLE, is often an important serological basis for the diagnosis of mixed connective tissue disease. Not suitable for the crowd Inappropriate people: no special requirements. Adverse reactions and risks There are no related complications and hazards.

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