Anti-double-stranded deoxyribonucleic acid antibody (dsDNA)

Anti-dsDNA antibodies have high specificity for the diagnosis of SLE. These anti-dsDNA antibodies are deposited in the microvascular basement membrane of each organ and react with the in situ antigenic DNA of the organ to form an immune complex, activate the inflammatory system, and cause tissue damage. Such as lupus nephritis, autoimmune hepatitis and so on. Animal models confirm that macromolecular DNA is involved in the pathogenesis of SLE. The anti-dsDNA antibody has a high titer in the serum of patients with active SLE, and the anti-dSDNA antibody titer decreases or disappears when the disease activity period is controlled. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Normal: Serum is negative. Positive: It has high specificity for systemic lupus erythematosus (SLE), but the sensitivity is slightly worse. The increase and decrease of anti-dsDNA antibody titer is related to the activity of SLE disease, so the condition of SLE can be monitored. In other patients with connective tissue disease, dsDNA can also be positive. Tips: Generally, it is an empty stomach check in the morning, after taboo eating or after eating spicy food. Normal value Serum was negative. Clinical significance Abnormal results: High specificity for systemic lupus erythematosus (SLE), but the sensitivity is slightly worse. The rise and fall of anti-dsDNA antibody titers is related to the activity of SLE disease, so the condition of SLE can be monitored. In other patients with connective tissue disease, dsDNA can also be positive. People who need to be examined: Patients with systemic lupus erythematosus and other connective tissue patients can be examined. Positive results may be diseases: fibrosis syndrome, lupus nephritis, urticaria vasculitis considerations Taboo before the test: Generally, it is an empty stomach check in the morning, and it is forbidden to check after eating or eating spicy food. Requirements for inspection: Note that serum specimens are not contaminated, resulting in false positives, which should be promptly sent for inspection. Inspection process Fluorescent immunoassay is a specific antibody or antigen labeled with a fluorescent substance as a standard reagent for the analytical identification and quantitative determination of the corresponding antigen or antibody. Fluorescent immunoassays include fluorescent antibody staining techniques and fluorescent immunoassays. Fluorescent antibody staining is the identification and localization of antigens or antibodies in cells, tissue sections or other specimens using fluorescent antibodies. The results can be directly observed under a fluorescence microscope, called fluorescence immunoscopy, or flow cytometry. The instrument performs automatic analysis and detection, which is called flow fluorescence immunoassay. Fluorescence immunoassays mainly include time-resolved fluorescence immunoassays and fluorescence polarization immunoassays. Not suitable for the crowd Inappropriate people: no special requirements. Adverse reactions and risks There are no related complications and hazards.

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