anti-ENA antibody

An anti-ENA antibody is an antibody that extracts a nuclear antigen from saline. It is an autoantibody against small molecule nuclear ribonucleoprotein (snRNPs) and small molecule cytoplasmic ribonucleoprotein (scRNPs), which is free of histones. There are mainly seven anti-Sm antibodies, anti-SS-A/Ro antibodies, anti-SS-B/La antibodies, anti-Scl-70 antibodies, anti-Jo-1 antibodies, anti-U1-RNP antibodies, anti-r-RNP antibodies. It is important for the diagnosis and differential diagnosis of connective tissue diseases, and has no significant correlation with disease severity and activity. The determination of T lymphocyte subsets is an important indicator for detecting cellular immune function, and it is helpful for the diagnosis of certain diseases (such as autoimmune diseases, immunodeficiency diseases, malignant tumors, blood diseases, allergic diseases, etc.). Mechanism, observation of efficacy and monitoring of prognosis are of great significance. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: No relevant information. Tips: Taboo overeating and strenuous exercise, should be calm, fasting blood test. Normal value Normal human serum anti-ENA antibodies were negative. Clinical significance Abnormal results: 1. Anti-Sm antibody, like anti-dsDNA, is highly specific for SLE and can be positive for anti-Sm regardless of active phase. It can be used as a marker antibody for SLE. However, anti-Sm positive patients account for only about 30% (20% to 40%) in SLE patients. Therefore, the diagnosis of SLE cannot be ruled out when anti-Sm is negative. There is no consensus on the relationship between anti-Sm antibody and clinical symptoms and disease outcome. . 2, anti-U1-RNP autoantibodies can be detected in the blood of a variety of rheumatic patients, SLE patients with a positive rate of 30% to 50%; systemic progressive sclerosis (PSS) 25% to 30%; dermatomyositis 10% to 20%, rheumatoid arthritis 5% to 10%, and in patients with mixed connective tissue disease (MCTD), high titer anti-U1-RNP antibody detection rate can reach 100%, these patients often Other specific autoantibodies. Anti-U1-RNP antibody (anti-70kD) was positively associated with myositis, esophageal motor dysfunction, and Raynaud's phenomenon, but more positive patients did not develop nephritis. 3. Anti-SS-A/Ro antibodies are associated with several autoimmune diseases. Most common in Sjogren's syndrome (40% to 95% of cases), also seen in systemic lupus erythematosus (20% to 60%) and primary biliary cirrhosis (20%), occasionally in chronic active hepatitis. 4. Anti-SS-B/La antibodies are almost exclusively found in female patients (29:1) and can occur in patients with Sjogren's syndrome (40% to 95% of patients) and systemic lupus erythematosus (10% to 20%). 5. Anti-Scl-70 antibody is mainly found in diffuse type in systemic progressive sclerosis (PSS). It is a marker antibody for the disease, and its positive rate is 25% to 70%. It can be as high as 75% in patients with severe diffuse scleroderma, and only 4% to 11% in patients with CREST syndrome. Antibody-positive anti-centromere antibodies were mostly negative. In patients with localized scleroderma, the detection rate of this antibody is very low, only about 20%. Anti-Jo-1 has certain value for polymyositis (PM) and dermatomyositis (DM); anti-ribosomal (Rib) antibodies are mainly found in SLE, and some people think that it can also be used as an SLE marker antibody, which is an indicator of lupus activity. People to be examined: patients with systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, and scleroderma. High results may be diseases: idiopathic arthralgia syndrome, juvenile rheumatoid arthritis, systemic lupus erythematosus Taboo before the examination: taboo overeating and strenuous exercise, should be calm, fasting blood test. Requirements for inspection: Note that serum samples are not contaminated and sent to the test in time. Follow the doctor's request. Inspection process The positive antibody can be determined by comparing the color band on the film strip with the antibody standard band with the ENA autoantibody spectrum standard band. Not suitable for the crowd Inappropriate people: no special requirements. Adverse reactions and risks There are no related complications and hazards.

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