Detection of Treponema pallidum by genetic diagnosis technology

The gene diagnostic technique for detecting Treponema pallidum is an examination method for identifying whether syphilis is infected by using genetic diagnosis technology. Gene diagnostic techniques detect Treponema pallidum. Treponema pallidum cannot be cultured in vitro. The most sensitive and reliable method for detecting Treponema pallidum in clinical specimens is the rabbit infection test (RIT). RIT can confirm the presence of live Treponema pallidum and is a standard method commonly used to detect Treponema pallidum. However, routine diagnosis of neonatal or adult syphilis with RIT is not practical. The serological diagnosis of syphilis is significant for the identification of infections and treatments, but is not sensitive to the diagnosis of early syphilis and is not specific enough for the diagnosis of congenital and neurosyphilis. Basic Information Specialist Category: Infectious Diseases Inspection Category: Genetic Testing (DNA) Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Infected with syphilis. Tips: Pay attention to normal eating habits, pay attention to personal hygiene, and prohibit unclean sexual intercourse. Normal value The test was negative, that is, no Treponema pallidum DNA was detected. Clinical significance Non-treponema pallidum antigen serum tests are currently generally used as screening and quantitative tests to observe efficacy, recurrence and reinfection. Abnormal results The abnormal results of syphilis in different periods are different: 1 stage syphilis: that is, hard chancre, incubation period of 2 to 4 weeks, dark red hard mass, shallow ulcer, external cartilage, cartilage-like hardness, peripheral lymph nodes. 2 secondary syphilis: After 1 to 2 months of syphilis in the first stage, the skin and mucous membranes of the whole body are symmetrically rash, rash, papules, pustules, etc. Mucosal plaques, flat wet phlegm can occur in the mucosa, and the infection is strong. 3rd stage syphilis: occurs 2 to 3 years or even 10 years after infection, the skin is a gum-like swelling, and may also involve bone, joint, heart, blood vessels, manifesting aortic inflammation, aortic insufficiency and aortic aneurysm, etc. Invading the nerves for spinal cord spasm, generalized paralysis (paralytic dementia). Congenital syphilis has early congenital syphilis, equivalent to the second day of the day, but heavier. Late congenital syphilis is similar to the acquired day, but few heart, blood vessel and neuropathy occur. Mainly for substantial keratitis, neurological deafness, Hutchinson's teeth (central incisors in the upper incisors, small upper and upper, equal width and width), sabre-shaped humerus and so on. There may be latent syphilis between stages, asymptomatic, and only seropositive. The treatment uses penicillin or erythromycin, tetracycline, and the like. The people who need to be examined are: those with septic symptoms such as hard chancre, rash, pimples, pustular rash, neurological deafness, and Hutchinson's teeth. Positive results may be diseases: primary syphilis, secondary syphilis, third-stage syphilis, pediatric yaw disease considerations Forbidden before examination: Pay attention to normal eating habits and pay attention to personal hygiene. Prohibition of unclean sexual intercourse. Requirements for inspection: Actively cooperate with the doctor. Inspection process Gene diagnostic technique for detection of Treponema pallidum Treponema pallidum cannot be cultured in vitro. The most sensitive and reliable method for detecting Treponema pallidum in clinical specimens is the rabbit infection test (RIT). RIT can confirm the presence of live Treponema pallidum and is a standard method commonly used to detect Treponema pallidum. However, routine diagnosis of neonatal or adult syphilis with RIT is not practical. The serological diagnosis of syphilis is significant for the identification of infections and treatments, but is not sensitive to the diagnosis of early syphilis and is not specific enough for the diagnosis of congenital and neurosyphilis. Serological tests are used as adjunctive diagnosis of congenital syphilis. The primary problem is to distinguish asymptomatic infected infants from non-infected infants. The mother's mother's syphilis test is positive. The difficulty is that the mother's humoral immune response cannot be compared with the infant's antibody. The response is different because the mother's IgG can be passed on to the fetus. In addition, since IgG exists for life, it is difficult to evaluate the treatment results. There are often false positives in serological diagnosis. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.

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