erythrocyte adenylate kinase

Erythrocyte adenylate kinase is a transferase in erythrocyte lysosomes and is mainly involved in nucleic acid and lipid metabolism. Determination of ADK is important for revealing certain diseases in humans. For example, pyruvatekinase (PK) deficiency is a red blood cell enzyme that occurs second only to G-6-PD deficiency. It has been confirmed that PK deficiency is caused by abnormal PK gene, mainly PK gene point mutation, and a small number of patients show deletion or insertion. ATP deficiency is a factor in hemolysis caused by PK deficiency. PK activity assay is the primary means of diagnosing this disease. There is no specific treatment for this disease. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: People who are taking enzyme-related drugs are not suitable for examination. Normal value 1, customary units 258 ± 29.3 U / g Hb (± s). 7428 ± 850 U / 1012 RBC (± s). 87.7 ± 9.96 U / ml RBC (± s). 2, the legal unit 16.64 ± 1.89 mU / mol Hb (± s). 7.84 ± 0.85 nU / RBC (± s). Clinical significance Abnormal result Adenylate Kinasein erythrocyte activity is altered in patients with congenital anoxia (autosomal recessive inheritance). Lack of erythrocyte pyruvate kinase deficiency, chronic hemolysis and its comorbidities manifest different severity, can be severe neonatal jaundice, and even bilirubin encephalopathy. People who need to be checked Astragalus, anemia, bilirubin encephalopathy, hemolysis. Precautions Before the test: Adjust the body in strict accordance with the doctor's compliance. After the examination: do a genetic counseling, check the carriers of the disease-causing gene and give medical guidance on fertility issues. Inspection process Subjects were venously collected and assayed in time for serum separation. Tested by chemical methods. Not suitable for the crowd People who are taking enzyme-related drugs. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.

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