serum total iron binding capacity

Total iron binding capacity (TIBC) refers to the maximum amount of iron that can bind to all transferrin in 100 ml of serum. About 30% of the transferrin in the normal human blood circulation is saturated. The level of transferrin is usually determined indirectly by a method for determining total iron binding capacity. Since there is still a very small amount of iron in the serum combined with other proteins, the measured TIBC results do not fully accurately reflect the transferrin content. The simultaneous detection of TIBC and serum iron has a greater clinical significance. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Reduced transferrin synthesis suggests that there may be diseases such as cirrhosis and hereditary transferrin deficiency. Normal value: Male: 50-77μmol/L Female: 54-77μmol/L Infant: 18-72μmol/L Above normal: Increased transferrin synthesis suggests that there may be diseases such as iron deficiency anemia. negative: Positive: Tips: Before using the iron, use iron to treat or fast foods with high iron content, such as animal liver; fasting and iron complex substances, such as tea. Normal value Male: 50 to 77 μmol/L. Female: 54 to 77 μmol/L. Infant: 18 to 72 μmol/L. Clinical significance Increased in the following diseases: 1. Increased transferrin synthesis, such as iron deficiency anemia. 2. Increased release of transferrin from the mononuclear-macrophage system (hepatocyte necrosis). 3. Excessive iron absorption, such as repeated blood transfusions. Reduce the following diseases: 1. Reduced transferrin synthesis, such as cirrhosis, hereditary transferrin deficiency. 2. Increased transferrin loss, such as chronic kidney disease, uremia, etc. 3, acute and chronic infection, hemolytic anemia, tumors and so on. The result is low, the disease may be: the result of pediatric renal anemia is high. Possible diseases: pediatric Jacques syndrome, hemochromatosis precautions 1. Serum iron is highest in the morning in 1 day and gradually decreases in the afternoon. Blood samples should be taken on an empty stomach in the morning. 2, before the examination, use iron to treat or fast foods with high iron content, such as animal liver; fasting energy and iron complex substances, such as tea. 3, when women in the menstrual period, pregnancy and infant growth period, due to the increase in the body's iron requirements, serum iron can be reduced, is a physiological phenomenon. Inspection process Take 1 ml of serum (pulp), add 1 ml of iron standard application solution, mix, place for 5 min, add 200 mg of magnesium carbonate powder, mix, set at room temperature for 30 min, and mix once every 10 minutes. Centrifuge at 2500 rpm for 10 min. Mix, boil in a boiling water bath for 5 min, cool to room temperature, centrifuge to precipitate, take the supernatant (if not clear chloroform 1ml to remove fat), use 530nm or green filter colorimetric, adjust the absorbance to 0 point with a blank tube, read Take the absorbance of each tube. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., or who have consumed a lot of tea and consume high-iron food, may affect the results of the examination, and prohibit patients with a history of taking the drug in the near future. an examination. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.

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