Glycated hemoglobin

Hemoglobin A1 is the main glycated hemoglobin component. Under normal circumstances, glycosylated hemoglobin accounts for about 6% to 8% of total hemoglobin, and there is no difference in gender, age or race. When diabetic, glycated hemoglobin is 2 to 3 times higher than normal. And it is closely related to the fasting blood glucose level in the past 2 to 3 months. The higher the blood glucose concentration, the higher the relative percentage of glycated hemoglobin. Glycated hemoglobin declines slowly during the course of diabetes. Glycated hemoglobin is still elevated in patients with diabetes control and decreased blood glucose levels, so the determination of glycated hemoglobin can reflect the average blood glucose level of patients in the past 2 to 3 months, but does not reflect the recent blood glucose levels. The glycated hemoglobin assay is used to assess the degree of therapeutic control of diabetes. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Glycated hemoglobin can also be used to monitor changes in diabetes in diabetic patients during pregnancy. Normal value 4.72% ~ 8.12%. (Microcolumn chromatography). Clinical significance Glycated hemoglobin ≤ 10%, indicating that the blood sugar of diabetic patients has been controlled, 10% to 16%, indicating that the condition is controlled, ≥ 16 indicates that the blood sugar of diabetics is not controlled. High results may be diseases: diabetic cardiomyopathy, diabetic nephropathy in the elderly, precautions for childhood diabetes (1) Specimens of patients with hyperlipidemia can make the results of glycated hemoglobin higher. The use of salicylic acid, semi-lactic acid, etc. can make the measurement results low. (2) Glycated hemoglobin can also be used to monitor changes in diabetes mellitus in diabetic patients during pregnancy, and to help monitor the normal pregnancy of pregnant women with diabetes. Inspection process The test tube is added with 0.1 ml of serum (plasma) to be tested, and 0.1 ml of distilled water is added to the blank tube, and 4 ml of NBT reagent pre-warmed at 37 ° C is added, mixed, placed in a 37 ° C water bath for 15 min, immediately taken out, and cooled by running water (less than 25 ° C). ). After cooling for 15 minutes, the wavelength of the spectrophotometer is 550 mm, and the 10 mm optical path is zeroed by a blank tube, and the absorbance of the measuring tube is read. The results were found from the standard curve. Reported with fructosamine mmol/L. Not suitable for the crowd No indication of indications. Adverse reactions and risks Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.

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