DHT

Dihydrotestosterone (DHT) can be produced directly from the testes, or it can be converted from the surrounding tissues by androgens and estrogens as precursors. Testosterone can be converted to DHT by the action of 5α-reductase, and the biological activity of DHT is 2 to 3 times that of T. DHT can promote the normal development of the external genitalia and prostate, promote the maturation of sperm in the epididymis, and facilitate the emergence and maintenance of secondary sexual characteristics. DHT binds to specific proteins in the cytoplasm to form a DHT-receptor complex that moves to the nucleus where it undergoes structural changes and binds to nuclear chromatin to produce a male physiological effect. The metabolism of DHT is mainly reduced to 3α-androstanediol by β-ketosteroid dehydrogenase, and then combined with glucuronide to form androstane glycol glucuronide, which is excreted from the urine. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Decreased serum DHT in female vulvar sclerosing hyperplasia Normal value: Female: 0.3-1.4nmol/Lnmol/L Male: 2.1-10.3nmol/Lnmol/L Above normal: Serum DHT is elevated in patients with enlarged prostate. negative: Positive: Tips: Barbiturate sedatives, clomiphene citrate, gonadotropins and oral contraceptives can increase testosterone, and the results of androgen, dexamethasone, digoxin and alcohol are low. Normal value Female 0.3 ~ 1.4nmol / L; male 2.1 ~ 10.3nmol / L. Clinical significance (1) Due to hypothalamic-pituitary dysfunction, LH secretion from pituitary gland increases, LH/FSH ratio increases, and sustained high levels of LH can stimulate excessive secretion of T and DHT in the ovary. (2) Female genital sclerosing lichenoid hyperplasia serum DHT decreased. (3) Patients with prostatic hypertrophy have elevated serum DHT. (4) There is no testicular disease, cryptorchidism, 17α-hydroxylase deficiency, 3β-hydroxysteroid dehydrogenase deficiency and other male sexual dysfunction, serum T and DHT can be reduced. (5) Familial incomplete pseudohermaphroditism type II. As an autosomal recessive disorder, due to the severe deficiency or non-function of 5α-reductase, T can not be converted into active dihydrotestosterone (DHT) in the target organ, serum T is increased, and DHT is decreased. Low results may be diseases: male hypogonadism, high test results without testicular disease: polycystic ovary syndrome considerations Barbiturate sedatives, clomiphene citrate, gonadotropins and oral contraceptives can increase testosterone; androgen, dexamethasone, digoxin and alcohol make the results lower. Inspection process Number the tubes and check them. Not suitable for the crowd No taboos. Adverse reactions and risks No complications.

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