Glycylproline dipeptide aminopeptidase

Hopsu-Havu and Glenner first discovered and isolated Glycyl-proline-dipeptidylaminopeptidase (GPDA) from the commercial enzyme product Acylase I in 1966, and confirmed the rat liver and mouse kidney. GPDA is present in tissues such as pig kidney, human and various animal serum, human salivary glands and saliva, bovine and human dental pulp and gums. The content of GPDA in human submandibular glands is quite abundant. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Serum GPDA activity in patients with gastric cancer was significantly lower than that in the control group. Serum GPDA activity was significantly reduced in patients with acute lymphocytic leukemia, lymphosarcoma, and lymphoblastoma. Serum GPDA activity in patients with rheumatoid arthritis is slightly lower, but in severe cases, the decline is significant. Serum GPDA activity was significantly reduced in patients with systemic lupus erythematosus. Normal value: Glycylproline dipeptide aminopeptidase: 44-116 U/L Above normal: Hepatobiliary diseases: the average activity of serum GPAD in patients with primary liver cancer is more than 2 times of the reference value of the control. The mean value of serum GPDA activity in patients with secondary liver cancer is more than 3 times of the reference value of the control. In acute hepatitis, with or without jaundice, serum GPDA only It is mildly elevated and returns to normal time. The abnormal rate of chronic hepatitis or cirrhosis is lower than that of patients with acute hepatitis. The enzymatic activity of alcoholic hepatitis is collected and the abnormal rate is higher than that of cirrhosis. In patients with drug-induced liver damage or primary hepatic cirrhosis caused by intrahepatic cholestasis, serum GPDA is significantly elevated, and the positive rate is also significantly higher than other liver diseases, which has certain specificity and diagnostic value. negative: Positive: Tips: You can't eat breakfast in the morning when you take a blood test. Normal value Serum: 44 ~ 116U / L. Clinical significance Abnormal result 1. Hepatobiliary diseases: The average activity of serum GPAD in patients with primary liver cancer is more than 2 times of the reference value of the control. The mean value of serum GPDA activity in patients with secondary liver cancer is more than 3 times of the reference value. In acute hepatitis, with or without jaundice, serum GPDA is only slightly elevated and returns to normal time. The abnormal rate of chronic hepatitis or cirrhosis is lower than that of patients with acute hepatitis. The enzymatic activity of alcoholic hepatitis is collected and the abnormal rate is higher than that of cirrhosis. In patients with drug-induced liver damage or primary hepatic cirrhosis caused by intrahepatic cholestasis, serum GPDA is significantly elevated, and the positive rate is also significantly higher than other liver diseases, which has certain specificity and diagnostic value. 2, gastrointestinal disease: gastric cancer patients with serum GPDA activity was significantly lower than the control group. In patients with gastroduodenal diseases with markedly reduced serum GPDA activity, the diagnosis of gastric cancer should be considered. After gastric cancer resection, the patient's serum GPDA has an upward trend. 3. Other diseases: The serum GPDA activity of patients with acute lymphocytic leukemia, lymphosarcoma and lymphoblastoma is significantly reduced. Serum GPDA activity in patients with rheumatoid arthritis is slightly lower, but in severe cases, the decline is significant. Serum GPDA activity was significantly reduced in patients with systemic lupus erythematosus. 4. Urine GPDA: The activity of GPDA in urine is significantly increased in patients with chronic glomerulonephritis. Need to check the crowd Hepatobiliary, stomach, and kidney suspected that cancer cells need to be diagnosed. Low results may be diseases: high gastric cancer results may be diseases: precautions for primary liver cancer Note before inspection: 1, can not eat breakfast in the morning of blood tests. 2, it is best not to smoke, drink, stay up late before taking blood. Pay attention to rest. Requirements for inspection: 1, can not be nervous during the blood draw. 2. If you feel unwell when taking blood, you should inform the doctor immediately. Not suitable for people: There is no inappropriate crowd. Inspection process The GPDA kit has continuous monitoring and manual colorimetry. In patients with primary AFP who were negative and positive for serum AFP, the positive rate of elevated serum GPDA was basically the same, while the serum GPDA activity of patients with hepatic hemangioma was in the normal range. Serum GPDA decreased significantly in more than 70% of patients with gastric cancer. After gastric cancer resection, serum GPDA showed a trend of recovery. Serum GPDA assay is useful for identifying benign and malignant liver lesions, monitoring liver metastasis of cancer and detecting gastric cancer. Not suitable for the crowd no. Adverse reactions and risks no.

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