Antigastric parietal cell antibody

Anti-gastric parietal cell antibody (PCA) was first discovered in the serum of patients with malignant anemia by Taylor and others. Its target antigen is located in the membrane of the parietal cell secretory tubule microvilli, which is a kind of microsomal part in the cytoplasm and a kind on the plasma membrane lipoprotein. PCA has organ specificity and does not react with other organs other than the stomach, but has no species specificity. Therefore, rat or rabbit gastric parietal cells can be used as antigens. The Ig types of PCA are mainly IgG and IgA (also a small amount of IgM), IgG is mainly in serum, and IgA is more common in gastric juice.

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