Familial apolipoprotein B100 deficiency

Familial defective apolipoprotein B100 (FDB) was first discovered in 1986. In studying people with moderately elevated plasma cholesterol levels, Vega et al. Noted that a small number of subjects had a slow catabolism rate of low-density lipoprotein (LDL) in the body, and their LDL receptor function was normal, presumably due to LDL particles Caused by its own abnormalities.

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