Chronic progressive chorea

Huntington disease (HD) is a dominant hereditary neurological degenerative disease characterized by involuntary movements, mental disorders and progressive dementia. It belongs to the category of gene dynamic mutation disease or polyglutamine repetitive disease. Because of Huntington's disease, which is a prominent clinical symptom, the disease was named Grand Dance Disease, Huntington's Disease, Chronic Progressive Dance Disease or Hereditary Dance Disease. The disease was first described by American physician Huntington in 1872. Alzheimer observed pathological changes in 1911. In 1993, the pathogenic gene was determined to be located at position 63 of the short arm of the fourth pair of autosomes. Protein, named Huntingtin. Pathological changes are characterized by the loss of nerve cells in the striatum and cerebral cortex. Recently, nucleus inclusions and dystrophic neurites in the nucleus of ubiquitin-positive neurons have been found in the cerebral cortex.

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