Non-thyroid sick syndrome

When hunger or systemic diseases, the thyroid hormone concentration in the body often drops to the level of hypothyroidism. It has been thought that this is the body's compensatory response and the thyroid function is normal, so it is called euthyroid sick syndrome (ESS) However, in a severe disease state, the severely reduced thyroid hormone (T4) concentration is accompanied by an increase in mortality, so some people think it is poorly compensated, so it is now more likely to use the term without subjective color: non-thyroid disease syndrome (nonthyroid illness syndrome, NTIS). NTIS refers to the effects of acute and chronic nonthyroid illness (NTI) on the functional parameters of the normal thyroid gland, and the thyroid itself has no lesions. Changes in thyroid hormones are related to the severity and duration of the underlying NTI, regardless of the type of disease. It is common in fasting and chronic malnutrition, severe infections, burns, major surgery and trauma, heart, liver, kidney disease or failure.

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