Glycogen storage disease

Glycogen accumulation disease is a type of glycogen metabolism disorder caused by congenital enzyme deficiency. According to European data, the incidence is 1 / (20,000 to 25,000). There are at least 8 kinds of enzymes necessary for glycogen synthesis and catabolism. There are 12 types of clinical diseases caused by the deficiency of these enzymes, of which Ⅰ, Ⅲ, Ⅳ, Ⅵ and Ⅸ types are mainly liver diseases; Types Ⅴ and Ⅶ are mainly muscle tissue damage. These diseases have a common biochemical characteristic, which is that glycogen storage is abnormal, and most of them are increased storage of glycogen in liver, muscle, kidney and other tissues. Glycogen storage is normal in only a few diseased species, while the molecular structure of glycogen is abnormal.

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