Thrombotic thrombocytopenic purpura in pregnancy

Thrombotic thrombocytopenic purpura (TTP) is a rare microvascular thrombo-hemorrhagic syndrome, which is mainly characterized by fever, thrombocytopenic purpura, microvascular hemolytic anemia, central nervous system and kidney involvement, and is known as the pentagram The first three are called triads. Most of the disease is dangerous, with a mortality rate of 54%. Young women are slightly more likely to be of childbearing age, so they can be complicated during pregnancy. Symptoms can also occur within a few days after a therapeutic abortion, and they are particularly prone to occur after childbirth. There are also cases of oral contraceptives and hysterectomy. It has been reported that TTP occurs in several members of the same family, and one group of cases, two sisters, developed the disease several years apart, all during pregnancy. In 1955, Miner first reported pregnancy complicated with this disease, and so far only dozens of cases with concomitant pregnancy have been reported.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.