Absence of vas deferens

Lack of vas deferens is a congenital malformation of the male reproductive system, and is an important cause of obstructive azoospermia and male infertility. The disease was discovered as early as the mid-18th century, but due to the limitations of diagnostic methods, only 25 cases were reported worldwide until the first half of the 20th century. Since then, with the improvement of male infertility diagnosis and treatment technology, case reports have continued to increase. Since 1985, more than 170 cases and treatment studies have been reported in China. Nevertheless, the etiology of the disease remains unclear. In the past more than 10 years, as the etiology of the disease has been gradually deepened, the relationship between the absence of vas deferens and cystic fibrosis (CF) has received widespread attention. The in-depth study of the latter has made congenital vas deferens lack The molecular biology basis has been revealed.

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